Excess caloric intake and low physical activity have been well known to cause obesity, metabolic syndrome, and diabetes mellitus, all of which increase risk of developing cardiovascular diseases and thus shorten life-span with good health in an ageing society. An increasing number of patients have recently suffered from these metabolic diseases due to a lack of effective prophylactic agents and methods. In addition, disruption of regular lifestyle, biased-nutrient intakes and mental instability have been reported to further aggravate the disease conditions. In this research projects, we try to understand pathological significance and molecular mechanisms of stress responses against varied environmental factors including foods in the development and progression of these metabolic diseases, and aim to establish novel prophylaxis, new diagnostic methods, and effective therapies against the diseases. To this end, we will develop new disease models by changing species, strength, timing, duration, and their combination patterns of stresses on cells and animals to obtain varied stress responses of cells and organs at the levels of genes, proteins, and metabolites in detail by the integrative “omics analyses”. Based on these data, we try to disclose novel molecular mechanisms involved in development and progression of the metabolic diseases. We also hope to provide new biomarkers and standard protocols to assess disease conditions and therapeutic potentials of new agents and methods against the diseases.